A recent study suggests that individuals who stop using new GLP-1 drugs like semaglutide or tirzepatide may regain shed pounds much more quickly than those who stop traditional lifestyle regimens.
Findings released in a major medical journal points out that while obese people frequently drop a large proportion of their body weight while on the medication, the weight returns at an estimated rate of nearly a kilo each month after stopping.
"Users using such drugs must be aware of the risk of fast weight regain when the treatment ends," warns researcher Dr. Susan Jebb.
Such speed of regain suggests a return to original mass in about 18 months.
Weighing Therapies
The research, which looked at dozens of studies involving over 9,000 of participants, compared the results of these new drugs with conventional dieting.
Scientists note that individuals who shed pounds through dieting usually experience a more gradual weight regain—perhaps 100 grams monthly—after stopping.
The Reason for the Fast Rebound
Doctors suggest the mode of action of the jabs explains the heightened rebound.
These medications mimic a natural hormone called glucagon-like peptide-1, which moderates feelings of fullness.
"Artificially providing GLP-1 levels several times higher than normal could lead to the system to produce less of its endogenous hormone, and could lessen responsiveness to its actions," noted Dr. Adam Collins, a dietetics researcher.
"Discontinuation of this hormone supplement means hunger is unsuppressed, making excessive eating a significant risk."
An Ongoing Disease?
Medical guidelines recommend the injections for individuals with weight-linked health risks, accompanied by recommended diet and exercise modifications.
Many experts argue that, given the significant potential of relapse, the treatment should be considered life-long.
This view is supported by pharmaceutical companies, who say that the results "highlight the persistent character of excess weight," comparing it to managing diseases like high blood pressure.
Patient Testimonies
Users who have discontinued the jabs describe a intense resurgence of appetite.
"It was like a trigger that goes on and you become ravenous," said a patient.
This challenge is exacerbated if individuals have not established sustainable dietary or behavioural modifications during therapy.
Widespread Interest
Survey data indicate that a significant number of people in the UK have used these injections in the past year, with desire continuing to grow.
- Use is greater among women than males.
- The middle-aged demographic shows the highest usage rates.
- Many obtain the medications through private healthcare rather than the NHS.
In conclusion, clinicians caution that while these medications are effective agents for shedding pounds, they are not a standalone fix and long-term success hinges on combined lifestyle support.
